Cellular change also occurs in early-stage lung cancer, say researchers Cellular change considered to happen only in late-stage cancers to help tumors pass on also occurs in early-stage lung cancer in an effort to bypass growth controls, say researchers at Mayo Clinic in Florida. The locating, reported in the July 11 problem of Science Translational Medicine, represents a new knowledge of the extent of transformation that lung malignancy – and likely many other tumor types – go through early in disease advancement, the scientists say. They add that the discovery also factors to a potential strategy to halt this process, known as epithelial-mesenchymal transition, or EMT improve heart condition .
9, underlines the importance of hypoxia-inducible factors to advertise breast cancer metastasis. ‘Large levels of RhoA and ROCK1 were recognized to worsen outcomes for breast cancer patients by endowing cancer cells having the ability to move, but the trigger for his or her production was a mystery,’ says Gregg Semenza, M.D., Ph.D., the C. Michael Armstrong Professor of Medicine at the Johns Hopkins University School of Medicine and senior author of the article. ‘We now understand that the production of the proteins increases dramatically when breast tumor cells are exposed to low oxygen circumstances.’ To move, cancer tumor cells must make many adjustments to their internal structures, Semenza says.